Efeito do extrato aquoso de camomila (Chamomilla recutita L.) na prenhez de ratas e no desenvolvimento dos filhotes
Carregando...
Data
2013
TĂtulo da Revista
ISSN da Revista
TĂtulo de Volume
Editor
Resumo
Medicinal plants have active substances and their
toxic effect on the organism is often unknown or ignored by users. Chamomile has been widely
used by the population; however, it is contraindicated for pregnant women due to evidence of
its emmenagogue and relaxing activity on smooth muscles. For these reasons, the aim of this
study was to evaluate the effects of aqueous extract of chamomile on pregnancy and generated
offspring. Nine Wistar rats were divided into three groups, D1 and D2, which received chamomile
infusion at 5% and 10%, respectively, and the control group which received saline solution.
Treatments were administered from the 1 st to the 7 th day after breeding. The studied parameters
were abortion prevalence, maternal weight gain during pregnancy, fetal and maternal death, gross
fetal malformation, newborn number, weight and neurological reflexes of the offspring on the 1 st ,
3 rd , 5 th and 10 th days of life. There was pregnancy in 70% of control group, 40% of D1 and 80%
of D2. There was no difference in maternal weight gain on the 7 th and 21 st days; however, treated
groups had smaller weight gain, compared to control, on the 14 th day of pregnancy (p=0.04). The
differences among newborn numbers were not significant. As to weight of newborns, treated
animals had smaller weight gain on days 1, 3, 5 and 10 after birth (p=0.005; p=0.001; p<0.001;
p<0.001; respectively). For neurological effects, there were differences in postural reflex on
the 1 st day, resulting in acceleration; on the other hand, for grasp (p=0.006) and orienting reflex
(p=0.01), there was a delay in disappearing, and no changes occurred on the remaining days
for the other assessed parameters. Chamomile may influence maternal weight gain during
pregnancy, as well as offspring weight gain after birth, and may cause changes in neurological
reflexes. There was no alteration in the remaining studied parameters.
Descrição
Palavras-chave
Plantas na gravidez, TeratogĂȘnese, Camomila, Plants during pregnancy, Chamomile, Teratogenesis
Citação
ARRUDA, J. T.; APPROBATO, F. C.; SILVA, T. M.; MAIA, M. C. S.; APPROBATO, M. Efeito do extrato aquoso de camomila (Chamomilla recutita L.) na prenhez de ratas e no desenvolvimento dos filhotes. Revista Brasileira de Plantas Medicinais, PaulĂnia, v. 15, n. 1, p. 66-71, 2013.