Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17951
Tipo do documento: Artigo
Título: Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population
Autor: Mesquita, Wyara Elanne de Jesus Castro
Approbato, Mário Silva
Moura, Kátia Karina Verolli de Oliveira
Jesuíno, Rosália Santos Amorim
Abstract: The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N = 33), and azoospermic (N = 24) men were analyzed. The extracted DNA was amplified for the exon 1 region of the AR gene. There was a significant correlation between the ab- sence of exon 1 in the AR gene and spermatogenesis defects (P = 0.015). This association was significant in teratozoospermic men (51.5% of the sample). We found that lack of amplification of exon 1 of the AR gene by polymerase chain reaction is associated with morphological defects in the spermogram.
Palavras-chave: Androgen receptor
Teratozoospermia
AR gene
Spermatogenesis
Male infertility
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: MESQUITA, W. E. J. C.; APPROBATO, M. S.; MOURA, K. K. V. O.; JESUINO, R. S. A. Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a brazilian population. Genetics and Molecular Research, Ribeirão Preto, v. 8, n. 4, p. 1423-1426, Nov. 2009.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/17951
Data de publicação: 2009
Aparece nas coleções:FM - Artigos publicados em periódicos

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