Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17953
Tipo do documento: Artigo
Título: Y chromosome microdeletions in brazilian fertility clinic patients
Autor: Arruda, Jalsi Tacon
Bordin, Bárbara Mariotto
Santos, P. R.
Mesquita, Wyara Elanne de Jesus Castro
Silva, R. C. P. C.
Maia, M. C. S.
Approbato, Mario Silva
Florêncio, Rodopiano de Souza
Amaral, Waldemar Naves do
Rocha Filho, M. A.
Moura, Katia karina Verolli de Oliveira
Abstract: Microdeletions in Yq are associated with defects in spermatogenesis, while those in the AZF region are considered criti- cal for germ cell development. We examined microdeletions in the Y chromosomes of patients attended at the Laboratory of Human Repro- duction of the Clinical Hospital of the Federal University of Goiás as part of a screening of patients who plan to undergo assisted reproduc- tion. Analysis was made of the AZF region of the Y chromosome in men who had altered spermograms to detect possible microdeletions in Yq. Twenty-three patients with azoospermia and 40 with severe oligo- zoospermia were analyzed by PCR for the detection of six sequence- tagged sites: sY84 and sY86 for AZFa, sY127 and sY134 for AZFb, and sY254 and sY255 for AZFc. Microdeletions were detected in 28 patients, including 10 azoospermics and 18 severe oligozoospermics. The patients with azoospermia had 43.4% of their microdeletions in the AZFa region, 8.6% in the AZFb region and 17.4% in the AZFc region. In the severe oligozoospermics, 40% were in the AZFa region, 5% in the AZFb region and 5% in the AZFc region. We conclude that microde- letions can be the cause of idiopathic male infertility, supporting conclu- sions from previous studies.
Palavras-chave: Male infertility
Y microdeletions
AZF
Assisted human reproduction
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: ARRUDA, J. T. et al. Y chromosome microdeletions in brazilian fertility clinic patients. Genetics and Molecular Research, Ribeirão Preto, v. 6, n. 2, p. 461-469, 2007.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/17953
Data de publicação: 2007
Aparece nas coleções:FM - Artigos publicados em periódicos

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