Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18060
Tipo do documento: Artigo
Título: Effect of tamoxifen and raloxifene on the proliferative activity of the breast epithelium in premenopausal women
Autor: Lucato, Miliana Tostes
Freitas Júnior, Ruffo de
Moreira, Marise Amaral Rebouças
Bernardes Júnior, Júlio Roberto de Macedo
Pinto, Sebastião Alves
Paulinelli, Régis Resende
Soares, Leonardo Ribeiro
Abstract: Objectives: To compare the effects of tamoxifen and raloxifene on the proliferative activity of normal breast tissue in premenopausal women as measured by Ki-67/MIB-1 expression. Study design: A total of 48 women with benign breast nodules and a recommendation for surgical removal of the lesion took part in this study. They were randomized to use tamoxifen or raloxifene for 22 days, after which they were submitted to surgery. During the surgical procedure, a 1-cm fragment of normal breast tissue was removed to study Ki-67 expression. Results: The mean percentage ratios between immunolabeled and non-labeled cells were 2.02 ± 1.09 and 3.13 ± 3.23 for the tamoxifen and raloxifene groups, respectively. There was no statistically significant difference between the tamoxifen (n = 16) and raloxifene (n = 14) groups in relation to the immuno­ histochemical analysis of Ki-67 (P = 0.205). Conclusion: The results of this study showed no difference between tamoxifen and raloxifene with respect to the potential of these drugs to reduce the proliferative activity of the normal breast epithelium in premenopausal women.
Palavras-chave: Breast epithelium
Tamoxifen
Breast
Raloxifene
Ki-67
Premenopausal women
País: Gra-bretanha
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: LUCATO, Miliana T. et al. Effect of tamoxifen and raloxifene on the proliferative activity of the breast epithelium in premenopausal women. Clinical Medicine Insights: oncology, London, v. 9, p. 25-30, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4137/CMO.S22456
Identificador do documento: 10.4137/CMO.S22456
URI: http://repositorio.bc.ufg.br/handle/ri/18060
Data de publicação: 2015
Aparece nas coleções:FM - Artigos publicados em periódicos

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