Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18061
Tipo do documento: Artigo
Título: Reprogramming energy metabolism and inducing angiogenesis: co-expression of monocarboxylate transporters with VEGF family members in cervical adenocarcinomas
Autor: Pinheiro, Céline Marques
Garcia, Eduardo Anselmo
Santos, Filipa Morais
Moreira, Marise Amaral Rebouças
Almeida, Fábio Marques de
Ribeiro, Luiz Fernando Jubé
Queiroz, Geraldo Silva
Paula, Élbio Cândido de
Andreoli, Maria Antonieta Avilla
Villa, Luisa Lina
Longatto Filho, Adhemar
Baltazar, Fátima
Abstract: Background: Deregulation of cellular energetic metabolism was recently pointed out as a hallmark of cancer cells. This deregulation involves a metabolic reprogramming that leads to a high production of lactate. Lactate efflux, besides contributing for the glycolytic flux, also acts in the extracellular matrix, contributing for cancer malignancy, by, among other effects, induction of angiogenesis. However, studies on the interplay between cancer metabolism and angiogenesis are scarce. Therefore, the aim of the present study was to evaluate the metabolic and vascular molecular profiles of cervical adenocarcinomas, their co-expression, and their relation to the clinical and pathological behavior. Methods: The immunohistochemical expression of metabolism-related proteins (MCT1, MCT4, CD147, GLUT1 and CAIX) as well as VEGF family members (VEGF-A, VEGF-C, VEGF-D, VEGFR-1, VEGFR-2 and VEGFR-3) was assessed in a series of 232 cervical adenocarcinomas. The co-expression among proteins was assessed and the expression profiles were associated with patients’ clinicopathological parameters. Results: Among the metabolism-related proteins, MCT4 and CAIX were the most frequently expressed in cervical adenocarcinomas while CD147 was the less frequently expressed protein. Overall, VEGF family members showed a strong and extended expression with VEGF-C and VEGFR-2 as the most frequently expressed and VEGFR-1 as the less expressed member. Co-expression of MCT isoforms with VEGF family members was demonstrated. Finally, MCT4 was associated with parametrial invasion and HPV18 infection, CD147 and GLUT1 with distant metastasis, CAIX with tumor size and HPV18 infection, and VEGFR-1 with local and lymphnode metastasis. Conclusions: The results herein presented provide additional evidence for a crosstalk between deregulating cellular energetics and inducing angiogenesis. Also, the metabolic remodeling and angiogenic switch are relevant to cancer progression and aggressiveness in adenocarcinomas.
Palavras-chave: Angiogenesis
VEGF
Cervical adenocarcinoma
Monocarboxylate transporter
HPV
Metabolic reprogramming
Hypoxia
Lymphangiogenesis
País: Estados unidos
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: PINHEIRO, Céline et al. Reprogramming energy metabolism and inducing angiogenesis: co-expression of monocarboxylate transporters with VEGF family members in cervical adenocarcinomas. BMC Cancer, New York, v. 15, p. 1- 11, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1186/s12885-015-1842-4
Identificador do documento: 10.1186/s12885-015-1842-4
URI: http://repositorio.bc.ufg.br/handle/ri/18061
Data de publicação: 2015
Aparece nas coleções:FM - Artigos publicados em periódicos

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