Expressão de receptores de estrogênio, progesterona e Ki-67 em transexuais feminino para masculino em uso de androgênios
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Data
2014
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Resumo
Introduction: The female to male transsexual patients use androgens for a prolonged period and
often without any medical supervision. Endogenous androgens have inhibitory effects on breast tissue,
while exogenous testosterone may exert an indirect effect on the breast because of its aromatization into
estrogen and it may even increase the risk of breast cancer. The Ki-67 is one of the most used antibodies
for evaluation of cell proliferation. Objectives: Evaluate the expression of estrogen and progesterone
receptors and Ki-67 expression in breast tissue of female to male transsexuals, biological women and
men with gynecomastia. Methods: The study consists of a case series of 17 patients, 5 transgender sub-
mitted to adenomastectomy as part of their treatment at the Service to Transgenders provided by the “Hospital das Clínicas” of the Federal University of Goiás, 4 women who underwent breast reduction
and 8 biological men that underwent surgery for gynecomastia. All surgical specimens were evaluated
by immunohistochemistry. R
esults: The transsexuals had a lower rate of expression of estrogen and
progesterone receptors compared with biological men and women, and in all patients using androgen
the expression of Ki-67 was ≤1%. The highest rate of expression of Ki-67 was 4.18% in a man with
gynecomastia. Conclusion: The expression of estrogen and progesterone receptor is lower in female to
male transsexual patients who used androgens in relation to biological men and women. The rate of
expression of Ki-67 is also lower in transsexuals.
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Transgendered persons, Biological markers, Androgens, Transexuais, Marcadores biológicos, Androgênios
Citação
COSTA, Ana Clara Araújo; NUNES, Aline Regina; RAHAL, Rosemar Macedo de Souza; SILVEIRA, Mariluza Terra; MOREIRA, Marise Amaral Rebouças; SUGITA, Denis Masashi; SUGITA, Denis Masashi; Freitas-Junior, Ruffo . Expressão de receptores de estrogênio, progesterona e Ki-67 em transexuais feminino para masculino em uso de androgênios. Revista Brasileira de Mastologia, Rio de Janeiro, v. 24, n. 2, p. 52-56, 2014.