Doença de Paget da mama: experiência de um centro universitário
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Data
2015
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Resumo
Objective: To determine the prevalence of Paget’s disease of the breast (PD) among cases of ductal
carcinomas diagnosed in a university hospital between 2003 and 2007; describe clinical charac-
teristics and analyze the survival of these cases. Methods: Retrospective cohort study, by reviewing
medical records. Frequency analysis was performed for all variables and used Kaplan-Meier curve for
the representation of overall survival. Results: In 278 cases of breast ductal carcinoma, 14 cases were
PD determining prevalence of 5.0%. A case was excluded from analysis because of incomplete data.
The mean age at diagnosis was 57.1 (±11.2) years. Of the cases analyzed, 11 (84.6%) had palpable
tumor and 9 (69.3%) presented lesion of the nipple-areola complex. Only one case was not submit-
ted to mastectomy because she died during neoadjuvant chemotherapy. Radiotherapy was performed
in six cases (46.2%); chemotherapy in eleven cases (84.6%); endocrinoterapia in six cases (46.2%). mmunohistochemistry identified five cases (38.5%) with expression of hormone receptors and twelve
patients (92.3%) with overexpression of HER2. The overall survival of patients was 61.5 (±13.4)
months, and there was no local recurrence after a mean follow-up of 75.8 months. Conclusion: There
was a prevalence of Paget’s disease of the breast associated with invasive carcinomas with advanced
clinical stages; which possibly resulted in overall survival rate lower than that observed in other studies
for the region.
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Breast neoplasms, Mammary Survivorship (public health), Paget’s Disease, Eczema, Neoplasias da mama, Eczema, Doença de Paget da mama, Sobrevida
Citação
CIRQUEIRA, Magno Belém; SOARES, Leonardo Ribeiro;MOREIRA, Marise Amaral Rebouças; ROSA, Victor Domingos Lisita; FREITAS-JUNIOR, Ruffo.Doença de Paget da mama: experiência de um centro universitário. Revista Brasileira de Mastologia, Rio de Janeiro, v. 25, n. 3, p. 90-96, 2015.