Investigation of the toxic potential of crude ethanol extract of Annona coriacea (araticum) seeds in acute exposed mice
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Data
2012-06
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Resumo
In this study, Annona coriacea Mart., Annonaceae, was examined for
possible toxic effects on brain, liver and kidney of mice exposed to crude extract
of the seeds (CESAN) of this plant. CESAN was administered by gavage for four
days at doses of 12.5, 25, 50, and 100 mg/kg/day. Significant changes on liver
were observed, which showed reduction in the number of hepatocytes per area and
increase the apoptotic index in the exposed groups, and changes in the cytoplasm
and nucleus of these cells and reduced consumption of water and feed in these
animals. For the other studied areas, brain and kidneys showed no changes in the
parameters used in this study. The results suggest hepatotoxic effects of CESAN, but
without damage to brain and kidneys in this experiment, showing a toxic potential to
this species, as to the Annonaceae family.
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Annonaceae, Annona coriacea, Araticum, Hepatotoxicity, Plant toxicity
Citação
NASCIMENTO, Guilherme Nobre L. do ; VALADARES, Marize Campos ; NISHIJO, Hisao; AVERSI-FERREIRA, Tales Alexandre. Investigation of the toxic potential of crude ethanol extract of Annona coriacea (araticum) seeds in acute exposed mice. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 3, p. 580-586, May/June 2012.