Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18089
Tipo do documento: Artigo
Título: Development and characterization of PLGA nanocapsules of grandisin isolated from Virola surinamensis: in vitro release and cytotoxicity studies
Autor: Stecanella, Luciano Aparecido
Taveira, Stephânia Fleury
Marreto, Ricardo Neves
Valadares, Marize Campos
Vieira, Marcelo de Sousa
Kato, Massuo Jorge
Lima, Eliana Martins
Abstract: The most studied phyto constituent isolated from Virola surinamensis (Rol. ex Rottb.) Warb., Myristicaceae, is the tetrahydrofuran neolignan grandisin, which exhibits a series of biological activities, including trypanocidal, larvicidal and antitumoral. Due to its extremely low solubility, additional studies, including in vivo investigations are challenged by the diffi culties in the development of an effective drug delivery system for grandisin. The encapsulation in polymeric nanoparticles is a very attractive alternative for overcoming some of these limitations. In this work, PLGA nanocapsules loaded with grandisin were developed in an attempt to optimize the effi cacy of grandisin as an antitumoral drug, with high drug loading and effi ciency, prolonged drug release and increased physical-chemical stability. Mean diameter of the nanocapsules was lower than 200 nm, with very low polydispersity. Encapsulation effi ciency was above 90%. A sustained in vitro drug release was achieved for up to twenty days and cytotoxicity was markedly increased (IC50 for grandisin-NC and grandisin were 0.005 μM and 0.078 μM, respectively), indicating that polymeric nanocapsules are a potential drug delivery system for grandisin allowing the preparation of formulations viable for further in vivo studies.
Palavras-chave: Cytotoxicity
Grandisin
PLGA nanocapsules
Sustained release
País: Brasil
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: STECANELLA, Luciano Aparecido et al. Development and characterization of PLGA nanocapsules of grandisinisolatedfrom Virolasurinamensis: in vitro release and cytotoxicity studies. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 1, p. 153-159, 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0102-695X2012005000128
Identificador do documento: 10.1590/S0102-695X2012005000128
URI: http://repositorio.bc.ufg.br/handle/ri/18089
Data de publicação: Fev-2013
Aparece nas coleções:FM - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Luciano Aparecido Stecanella - 2013.pdf717,94 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons