Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18146
Tipo do documento: Artigo
Título: Relevance of target-organ lesions as predictors of mortality in patients with diabetes mellitus
Autor: Bianco, Henrique Tria
Izar, Maria Cristina de Oliveira
Fonseca, Henrique Andrade Rodrigues da
Póvoa, Rui Manuel dos Santos
Saraiva, José Francisco Kerr
Forti, Adriana Costa e
Jardim, Paulo César Brandão Veiga
Introcaso, Luiz Antonio Ribeiro
Toledo, Juan Carlos Yugar
Xavier, Hermes Toros
Faludi, André Arpad
Fonseca, Francisco Antonio Helfenstein
Abstract: Background: Patients with diabetes are in extract higher risk for fatal cardiovascular events. Objective: To evaluate major predictors of mortality in subjects with type 2 diabetes. Methods: A cohort of 323 individuals with type 2 diabetes from several regions of Brazil was followed for a long period. Baseline electrocardiograms, clinical and laboratory data obtained were used to determine hazard ratios (HR) and confidence interval (CI) related to cardiovascular and total mortality. Results: After 9.2 years of follow-up (median), 33 subjects died (17 from cardiovascular causes). Cardiovascular mortality was associated with male gender; smoking; prior myocardial infarction; long QTc interval; left ventricular hypertrophy; and eGFR <60 mL/min. These factors, in addition to obesity, were predictors of total mortality. Cardiovascular mortality was adjusted for age and gender, but remained associated with: smoking (HR = 3.8; 95% CI 1.3-11.8; p = 0.019); prior myocardial infarction (HR = 8.5; 95% CI 1.8-39.9; p = 0.007); eGFR < 60 mL/min (HR = 9.5; 95% CI 2.7-33.7; p = 0.001); long QTc interval (HR = 5.1; 95% CI 1.7-15.2; p = 0.004); and left ventricular hypertrophy (HR = 3.5; 95% CI 1.3-9.7; p = 0.002). Total mortality was associated with obesity (HR = 2.3; 95% CI 1.1-5.1; p = 0.030); smoking (HR = 2.5; 95% CI 1.0-6.1; p = 0.046); prior myocardial infarction (HR = 3.1; 95% CI 1.4-6.1; p = 0.005), and long QTc interval (HR = 3.1; 95% CI 1.4-6.1; p = 0.017). Conclusions: Biomarkers of simple measurement, particularly those related to target-organ lesions, were predictors of mortality in subjects with type 2 diabetes.
Palavras-chave: Diabetes mellitus
Type 2
Type 2
Diabetes mellitus
Epidemiology
Mortality
Complications
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: BIANCO, Henrique Tria et al. Relevance of target-organ lesions as predictors of mortality in patients with diabetes mellitus. Arquivos Brasileiros de Cardiologia, São Paulo, v. 103, n. 4, p. 272-281, Aug. 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.5935/abc.20140112
Identificador do documento: 10.5935/abc.20140112
URI: http://repositorio.bc.ufg.br/handle/ri/18146
Data de publicação: Ago-2014
Aparece nas coleções:FM - Artigos publicados em periódicos

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