Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18193
Tipo do documento: Artigo
Título: Brazilian multicenter study on efficacy and tolerability of trandolapril in mild-to-moderate essential arterial hypertension. EMBATHE substudy with ambulatory blood pressure monitoring
Autor: Kohlmann Junior, Osvaldo
Jardim, Paulo Cesar Brandao Veiga
Oigman, Wille
Abstract: Objective - A double-blind, placebo-controlled multi- center study involving 34 centers from different Brazilian regions was performed to evaluate the antihypertensive efficacy and tolerability of trandolapril, an angiotensin I converting enzyme inhibitor, in the treatment of mild-to- moderate systemic arterial hypertension. Methods - Of 262 patients enrolled in this study, 127 were treated with trandolapril 2 mg/day for 8 consecutive weeks, and the remaining 135 patients received placebo for the same period of time. Reduction in blood pressure (BP) and the occurrence of adverse events during this period were evaluated in both groups. Results - Significant reductions in both systolic and diastolic pressures were observed in patients treated with trandolapril when compared with those on placebo. Antihypertensive efficacy was achieved in 57.5% of the patients on trandolapril and in 42% of these normal values of BP were obtained. The efficacy of trandolapril was simi- lar in all centers, regardless of the area of the country. In a subset of 30 patients who underwent ABPM, responders showed a significant hypotensive effect to trandolapril throughout the 24 hour day. The adverse event profile was similar in both trandolapril and placebo groups. Conclusion - Our results demonstrate, for the first time in a large group of hypertensive patients from different regions in Brazil, good efficacy and tolerability of trando- lapril during treatment of mild-to-moderate essential sys- temic hypertension.
Palavras-chave: Mild-to-moderate hypertension
ACE inhibitor
Trandolapril
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: KOHLMANN JR., Osvaldo; JARDIM, Paulo César B. Veiga; OIGMAN, Wille. Brazilian multicenter study on efficacy and tolerability of trandolapril in mild-to-moderate essential arterial hypertension. EMBATHE substudy with ambulatory blood pressure monitoring. Arquivos Brasileiros de Cardiologia, São Paulo, v. 72, n. 5, p. 547-552, May 1999.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0066-782X1999000500002 
Identificador do documento: 10.1590/S0066-782X1999000500002 
URI: http://repositorio.bc.ufg.br/handle/ri/18193
Data de publicação: 1999
Aparece nas coleções:FM - Artigos publicados em periódicos

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