Brazilian multicenter study on efficacy and tolerability of trandolapril in mild-to-moderate essential arterial hypertension. EMBATHE substudy with ambulatory blood pressure monitoring
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Data
1999
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Resumo
Objective - A double-blind, placebo-controlled multi-
center study involving 34 centers from different Brazilian
regions was performed to evaluate the antihypertensive
efficacy and tolerability of trandolapril, an angiotensin I
converting enzyme inhibitor, in the treatment of mild-to-
moderate systemic arterial hypertension.
Methods - Of 262 patients enrolled in this study, 127
were treated with trandolapril 2 mg/day for 8 consecutive
weeks, and the remaining 135 patients received placebo
for the same period of time. Reduction in blood pressure
(BP) and the occurrence of adverse events during this
period were evaluated in both groups.
Results - Significant reductions in both systolic and
diastolic pressures were observed in patients treated with
trandolapril when compared with those on placebo.
Antihypertensive efficacy was achieved in 57.5% of the
patients on trandolapril and in 42% of these normal values
of BP were obtained. The efficacy of trandolapril was simi-
lar in all centers, regardless of the area of the country. In a
subset of 30 patients who underwent ABPM, responders
showed a significant hypotensive effect to trandolapril
throughout the 24 hour day. The adverse event profile was
similar in both trandolapril and placebo groups.
Conclusion - Our results demonstrate, for the first
time in a large group of hypertensive patients from different
regions in Brazil, good efficacy and tolerability of trando-
lapril during treatment of mild-to-moderate essential sys-
temic hypertension.
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Mild-to-moderate hypertension, ACE inhibitor, Trandolapril
Citação
KOHLMANN JR., Osvaldo; JARDIM, Paulo César B. Veiga; OIGMAN, Wille. Brazilian multicenter study on efficacy and tolerability of trandolapril in mild-to-moderate essential arterial hypertension. EMBATHE substudy with ambulatory blood pressure monitoring. Arquivos Brasileiros de Cardiologia, São Paulo, v. 72, n. 5, p. 547-552, May 1999.