Diferentes terapias no tratamento da obesidade em pacientes hipertensos

Abstract

Purpose - To evaluate the efficacy and tolerability of different therapies associated with diet in the treatment of hypertensive obese patients. Methods - In a clinical study we randomly evaluated 39 hypertensive obese patients (body mass index (BMI) >30kg/m 2 ). After 45 days of diet the patients were again randomly distributed in 3 groups and received in double blind way: group 1 - hypocaloric diet + placebo; group 2 - hypocaloric diet + dexfenfluramine; group 3 - hypocaloric diet + spiruline+fucus+gelatine. We followed their progress during 12 weeks under medication and further 24 weeks without. We evaluated the groups comparing: weight, BMI, blood pressure and side-effects. Results - Twenty seven patients completed the obser- vation. In those patients from groups 1 and 3 no changes in any of parameters were observed. In group 2 we observed a clear loss of weight (-3.8Kg) and a fall in BMI. Blood Pressure changes were only observed in group 2 (-9.6%). The only patients to maintain weight loss after the termination of use of medicines were those from group 2. We did not observe any side-effects. Conclusion - In hypertensive obese patients, when isolated diet is not enough to control weight loss, dexfenflu- ramine could be useful in association with a controlled diet. The drug assists in weight loss, does not promote side- effects and does not interfere in the treatment of blood pres- sure.