Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18197
Tipo do documento: Artigo
Título: Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in central Brazil
Autor: Botelho, Silvia Marçal
Ferreira, Renata Carneiro
Reis, Nádia Rúbia da Silva
Kozlowski, Aline Garcia
Carneiro, Megmar Aparecida dos Santos
Yoshida, Clara Fumiko Tachibana
Martins, Regina Maria Bringel
Resumo: An investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence of 16.1% (95% CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated with HCV positivity. In HCV-positive patients, only 12.2% had ALT levels above normal. Twenty-eight samples were genotyped as genotype 1, subtypes 1a (62.5%) and 1b (31.3%), and two samples (6.2%) were genotype 3, subtype 3a. These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this population
Palavras-chave: Hepatitis C virus
Renal transplant recipients
Prevalence
Risk factors
ALT
Genotypes
País: Brasil
Unidade acadêmica: Faculdade de Enfermagem - FEN (RG)
Citação: Botelho, Silvia M.; FERREIRA, Renata C.; REIS, Nádia R. S.; KOZLOWSKI, Aline G.; CARNEIRO, Megmar A. S.; YOSHIDA, Clara F. T.; MARTINS, Regina M. B.; TELES, S. A. Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 472-476, Aug. 2008.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762008000500011
Identificador do documento: 10.1590/S0074-02762008000500011
URI: http://repositorio.bc.ufg.br/handle/ri/18197
Data de publicação: Ago-2008
Aparece nas coleções:FEN - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Silvia Marçal Botelho - 2008.pdf314,59 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons