Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18205
Tipo do documento: Artigo
Título: Rotavirus A infections and reinfections: genotyping and vaccine implications
Autor: Costa, Paulo Sérgio Sucasas da
Cardoso, Divina das Dôres de Paula
Grisi, Sandra Josefina Ferraz Ellero
Silva, Paula A.
Fiaccadori, Fabíola Souza
Souza, Menira Borges de Lima Dias e
Santos, Rodrigo A. T.
Abstract: Objective: To identify rotavirus A and the most prevalent G and P genotypes in children with acute diarrhea, and to the describe the occurrence of rotavirus infection and reinfection. Methods: Group A rotavirus specimens were obtained from fecal samples from children with acute diarrhea in Goiânia, state of Goiás, Brazil from July 2000 to October 2002. Rotavirus A positive children and a control group (children of the same age and sex, without diarrhea and with no evidence of rotavirus in the first fecal samples) were followed prospectively during one year. All rotavirus A positive samples were genotyped using RT-PCR/nested-PCR. Results: A total of 77 group A rotavirus strains (37.2%) were identified in the diarrheic samples of 207 children. The following G genotypes were identified: G1 (62.3%), G9 (34.4%) and G4 (3.3%). With regard to P genotyping, 59% were characterized as P[8], 7.7% as P[6], 23.1% as P[6]+P[8], 7.7% as P[4]+P[8] and 2.6% as P[4]+P[8]. The following associations were observed: G1P[8] (77.8%), G9P[8] (11.1%), G4P[8] (5.6%) and G1P[6] (5.6%). No reinfection was observed in the 40 rotavirus A (+) children. However, but two of 40 children who were initially negative for this agent developed rotavirus infection during the same period. Conclusions: The predominant G and P genotypes observed were similar to those found in new vaccines. No reinfection occurred during one-year of follow-up for any of the genotypes identified.
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: COSTA, Paulo S. S.; CARDOSO, Divina D. P.; GRISI, Sandra J. F. E.; SILVA, Paula A.; FIACCADORI, Fabíola; SOUZA, Menira B. L. D.; SANTOS, Rodrigo A. T. Rotavirus A infections and reinfections: genotyping and vaccine implications. Jornal de Pediatria, Porot Alegre, Rio de Janeiro, v. 80, n. 2, p. 119-122, 2004.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/18205
Data de publicação: 2004
Aparece nas coleções:FM - Artigos publicados em periódicos

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