Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18208
Tipo do documento: Artigo
Título: Hepatitis C virus infection in brazilian long-distance truck drivers
Autor: Freitas, Nara Rúbia de
Teles, Sheila Araujo
Matos, Marcos André de
Lopes, Carmem Luci Rodrigues
Reis, Nádia Rúbia da Silva
Santo, Marcia Paschoal do Espírito
Lampe, Elisabeth
Martins, Regina Maria Bringel
Abstract: Hepatitis C virus (HCV) infection is a global public health problem. Long-distance truck drivers live apart from their family for long periods of time, a lifestyle that favors at-risk behaviors such as unprotected sex with multiple partners and illicit drug use. As data concerning HCV infection in this population are still rare, this paper aims to investigate the prevalence, genotypes/subtypes, and the factors associated with HCV infection in long-distance truck drivers in Brazil. A cross-sectional survey was carried out with 641 Brazilian long-truck drivers who were recruited at a major truck stop located at kilometer 1,296 of the BR-153 highway, which is considered to be one of the longest roads in Brazil. All individuals were interviewed, and their serum samples were tested for the presence of antibodies to HCV (anti-HCV) by ELISA and immunoblot. Anti-HCV positive samples were tested for HCV RNA by PCR amplification of the 5′ NC and NS5B regions and were genotyped using the LiPA assay and nucleotide sequencing, respectively. Factors associated with HCV infection were identified with logistic regression. The prevalence of HCV infection was 1.4% (95% CI: 0.7-2.8). History of blood transfusion, sharing of personal hygiene tools, illicit drug use and HBV status were factors independently associated with HCV infection in the study population. HCV RNA was detected in 8/9 anti-HCV positive samples, in which genotypes 1 (n = 3), 2 (n = 2), and 3 (n = 3) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 1), 1b (n = 2), 2b (n = 2) and 3a (n = 3) were identified. These data show that the prevalence of HCV infection among Brazilian truck drivers was similar to that observed for the general population. History of blood transfusion, sharing of personal hygiene tools, illicit drug use and HBV status were predictors of HCV infection. The HCV genotypes/subtypes identified in the study population are consistent with those circulating in Brazil.
País: Outros
Unidade acadêmica: Faculdade de Enfermagem - FEN (RG)
Citação: FREITAS, Nara R.; TELES, Sheila A.; MATOS, Marcos A.; LOPES, Carmen L. R.; REIS, Nádia R. S.; SANTO, Márcia P. Espírito; LAMPE, Elisabeth; MARTINS, Regina M. B. Hepatitis C virus infection in brazilian long-distance truck drivers. Virology Journal, Londres, v. 7, n. 205, p. 1-6, 2010.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1186/1743-422X-7-205
Identificador do documento: 10.1186/1743-422X-7-205
URI: http://repositorio.bc.ufg.br/handle/ri/18208
Data de publicação: Ago-2010
Aparece nas coleções:FEN - Artigos publicados em periódicos

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