Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18235
Tipo do documento: Artigo
Título: Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
Autor: Santos, Silvia Helena Rabelo dos
Zeferino, Luiz Carlos
Villa, Luisa Lina
Sobrinho, J. P.
Amaral, Rita Goreti
Magalhães, A. V.
Abstract: This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalin- fixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction prod- ucts were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/ 58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively.
Palavras-chave: Human papillomavirus
Brazil
Cervical cancer
Goiás
Cervical intraepithelial neoplasia
Prevalence
Polymerase chain reaction
Dot blot hybridization
País: Brasil
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: RABELO-SANTOS, S. H.; ZEFERINO, L.; VILLA, L. L.; SOBRINHO, J. P.; AMARAL, R. G.; MAGALHÃES, A. V. Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil. Memorias do Instituto Oswaldo Cruz, Rio de Janeiro,v. 98, n. 2, p. 181-184, 2003.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/18235
Data de publicação: Mar-2003
Aparece nas coleções:FM - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Silvia Helena Rabelo dos Santos - 2003.pdf46,94 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons