Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18247
Tipo do documento: Artigo
Título: A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
Autor: Resende, Leandro Santos de Araújo
Santos, Silvia Helena Rabelo dos
Sarian, Luís Otávio Zanatta
Alves, Rosane Ribeiro Figueiredo
Ribeiro, Andréa Alves
Zeferino, Luiz Carlos
Derchain, Sophie Françoise Mauricette
Abstract: Background: Cervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single- (ST) and multiple-type (MT) HPV infections with patients’ age and lesion pathological status. Methods: 328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high- (hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata. Results: 287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59. Conclusions: Our data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18.
Palavras-chave: Human papillomavirus
Age
Cervical intraepithelial neoplasia
Prevalence
Genotype
País: Estados unidos
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: RESENDE, Leandro Santos de Araújo et al. A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions. BMC Infectious Diseases, v. 14, n. 214, New York, p. 1-8, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1186/1471-2334-14-214
Identificador do documento: 10.1186/1471-2334-14-214
URI: http://repositorio.bc.ufg.br/handle/ri/18247
Data de publicação: 2014
Aparece nas coleções:FM - Artigos publicados em periódicos

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