Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18284
Tipo do documento: Artigo
Título: In silico repositioning of new drugs against Schistosoma mansoni
Autor: Bezerra, José Clecildo Barreto
Arantes, Morgana Elias
Andrade, Carolina Horta
Silva, Lourival Almeida
Neves, Bruno Junior
Abstract: Schistosomiasis is a neglected tropical disease caused by parasites of the genus Schistosoma. In Brazil only Schistosoma mansoni causes this disease. The World Health Organization estimated in 2012 approximately 249 million people at risk of acquiring this disease around the world. The main strategy to control this disease is praziquantel treatment of individuals living in endemic areas. The drug praziquantel is used on a large scale in the treatment of schistosomiasis and currently there are reported cases of resistance, indicating the need to discover new drugs. In silico drug repositioning is a time and cost reducing strategy in the search for anti-Schistosoma agents. This work used bioinformatic tools to identify potential schistosomicidal drugs. A list was compiled of S. mansoni potential targets that are part of essential processes in the database TDR and the targets that are part of the tegument were obtained in the scientific literature. The file with S. mansoni targets contained 1,376 targets, and of these only 61 targets associated with 399 drugs had homology with drug targets. After removal of duplicate drugs, drugs found in previous studies and after the analysis of the conservation of the binding site, only 28 S. mansoni targets associated with 102 drugs had 60% or more of the active site conserved. Some of the drugs had activity and are interesting to validate this study such as: artemether, lumefantrine, meloxicam. Among the drugs found 18 drugs were selected to be tested in prospective experimental assays according to the following criteria: low toxicity in vivo, off-patent status, and logP <5.0.
Palavras-chave: Control
Schistosoma mansoni
Drug repositioning
Chemogenomics
País: Brasil
Instituição: Ruy de Souza Lino Junior
Sigla da instituição: UFG
Unidade acadêmica: Instituto de Patologia Tropical (IPTSP) - RG
Citação: BEZERRA, José Clecildo Barreto; ARANTES, Morgana Elias; ANDRADE, Carolina Horta; SILVA, Lourival Almeida; NEVES, Bruno Junior. In silico repositioning of new drugs against Schistosoma mansoni. Revista de Patologia Tropical, Goiânia, v. 47, n. 3, p. 159-166, jul./sep. 2018. Disponível em: https://www.revistas.ufg.br/iptsp/article/view/55429/26478.
Tipo de acesso: Acesso Aberto
Identificador do documento: 0.5216/rpt.v47i3.55429
Identificador do documento: 0.5216/rpt.v47i3.55429
URI: http://repositorio.bc.ufg.br/handle/ri/18284
Data de publicação: Set-2018
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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