Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18304
Tipo do documento: Artigo
Título: Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer
Autor: Zampronha, Rossana de Araújo Catão
Freitas Júnior, Ruffo de
Murta, Eddie Fernando Candido
Michelin, Márcia Antoniazi
D'Alessandro, Aline Almeida Barbaresco
Adad, Sheila Jorge
Oliveira, Amaurillo Monteiro de
Rassi, Amanda Bruder
Oton, Gloria Jabur Bittar
Abstract: OBJECTIVE: This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. METHODS: A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival. RESULTS: The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease- free survival was unaffected by the presence of HPV type 16 or 18. CONCLUSION: In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.
Palavras-chave: Human Papillomavirus (HPV)
Survival
Cervical cancer
Prognosis
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: ZAMPRONHA, Rossana de Araújo Catão et al. Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer. Clinics, São Paulo, v. 68, n. 6, p. 809-814, Jun. 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.6061/clinics/2013(06)14 ISSN 0041-8781
Identificador do documento: 10.6061/clinics/2013(06)14 ISSN 0041-8781
URI: http://repositorio.bc.ufg.br/handle/ri/18304
Data de publicação: 2013
Aparece nas coleções:FM - Artigos publicados em periódicos

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