Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18368
Tipo do documento: Artigo
Título: Incidence of ventricular arrhythmias after stem cell therapy in patients with Chagas cardiomyopathy
Autor: Souza, Adriana Sebba Barroso de
Souza, Weimar Kunz Sebba Barroso de
Costa, Sandra de Araujo
Freitas, Elis Marra de Moreira
Carvalho, Gustavo
Sa, Luiz Antonio Batista de
Rassi, Salvador
Abstract: Background: Treatment with stem cells in several cardiomyopathies may be related to the increase in arrhythmias. Objectives: To determine whether intracoronary injection of stem cells in patients with Chagas cardiomyopathy is associated with increased incidence of ventricular arrhythmias, compared to the Control Group. Methods: A retrospective cohort study that evaluated the medical records of 60 patients who participated in a previous cross-sectional study. The following data were collected: age, gender, drugs used and Holter variables that demonstrated the presence of arrhythmias. Holter was performed in four stages: randomization, 2, 6 and 12 months segments. The Control Group received medical treatment and intracoronary injection of placebo and the Study Group had drug treatment and autologous stem cell implant. Results: There was no difference between Control Group and Study Group when analyzing the arrhythmia criteria. In the intra-group analysis, significant difference was found between the Holter tests of the Study Group for the variable total ventricular premature beats when compared with baseline, with p = 0.014 between Holter at randomization and Holter at 2 months, p = 0.004 between Holter at randomization and Holter at 6 months, and p = 0.014 between Holter at randomization and Holter at 12 months. The variable non-sustained ventricular tachycardia between Holter at randomization and Holter at 6 months showed p = 0.036. Conclusion: The intracoronary injection of stem cells did not increase the incidence of ventricular arrhythmias in patients with Chagas cardiomyopathy compared to the Control Group.
Palavras-chave: Arrhythmias
Chagas cardiomyopathy
Cardiac
Stem cell transplantation
País: Brasil
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: SOUZA, Adriana Sebba Barroso de et al. Incidence of ventricular arrhythmias after stem cell therapy in patients with Chagas cardiomyopathy. Arquivos Brasileiros de Cardiologia, Rio de Janeiro, v. 102, n. 5, p. 489-494, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.5935/abc.20140053 
Identificador do documento: 10.5935/abc.20140053 
URI: http://repositorio.bc.ufg.br/handle/ri/18368
Data de publicação: 2014
Aparece nas coleções:FM - Artigos publicados em periódicos

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