Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18459
Tipo do documento: Artigo
Título: Transcriptome overview of Paracoccidioides brasiliensis proteases
Autor: Rocha, Juliana Alves Parente
Costa, Milce
Pereira, Maristela
Soares, Célia Maria de Almeida
Abstract: Proteases perform a wide variety of functions inside and outside cells, regulating many biological processes. Infectious microorganisms use proteases, either secreted or attached to their cell surface to weaken and invade their hosts. Therefore, proteases are targets for drugs against a diverse set of diseases. Paracoccidioides brasiliensis is the most prevalent fungal pathogen causing systemic mycosis in Latin America. The development of paracoccidioidomycosis depends on interactions between fungal and host components and proteases have been described as important factors implicated in the mechanism of host colonization by fungi. The primary goal for this study is to present an overview of the transcriptome sequences - identified cDNAs that encode proteases. We obtained a total of 53 cDNAs encoding proteases; 15 were classified as ATP-independent, 12 as ATP-dependent, 22 as proteasome subunits, and 4 as deubiquitinating proteases. The mechanisms and biological activity of these proteases differ in substrate specificity and in catalytic mechanisms.
Palavras-chave: Proteases
Proteasome
Paracoccidioides brasiliensis
Host-fungus interaction
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: PARENTE, Juliana Alves; COSTA, Milce; PEREIRA, Maristela; SOARES, Célia Maria de Almeida. Transcriptome overview of Paracoccidioides brasiliensis proteases. Genetics and Molecular Research, Rebeirão Preto, v. 4, n. 2, p. 358-371, 2005.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/18459
Data de publicação: 2005
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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