Prevalence, genotype profile and risk factors for multiple human papillomavirus cervical infection in unimmunized female adolescents in Goiânia, Brazil: a community-based stud
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2013
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Background: The epidemiology of infection with multiple human papillomavirus (HPV) types in female adolescents
is poorly understood. The purpose of this study was to explore the epidemiology of infection with multiple HPV
types in adolescents and its association with demographic, behavioral and biological variables, as well as with
cytological abnormalities.
Methods: This community-based study included 432 sexually active females between 15 and 19 years of age.
Genotyping for 30 HPV types was performed using a reverse blot strip assay/restriction fragment length polymorphism.
Unconditional multivariate logistic regression was performed to identify factors significantly associated with HPV
infection. The association between HPV infection and cytological abnormalities was calculated using a prevalence ratio.
Results: The most common HPV types detected were 16, 51, 31, 52 and 18. Of the 121 HPV-positive women, 54 (44.6%)
were infected with multiple HPV types. Having more than one lifetime sexual partner was associated with infection
with any HPV infection, single HPV infection, and infection with multiple HPV types. The presence of cytological
abnormalities was associated with infection with multiple HPV types.
Conclusions: Co-infecting HPV genotypes occur in a high proportion of sexually active adolescents. Socio-demographic
or sexual behavior factors associated with single HPV infection were similar to those associated with multiple HPV types.
The higher risk of cytological abnormalities conferred by infection with multiple HPV types suggests a potential role of
co-infection in the natural history of HPV infection.
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Cytological abnormalities, Epidemiology, Multiple HPV infection, PCR-PGMY09/11/line blot hybridization/RFLP, Adolescents, Female
Citação
ALVES,Rosane Ribeiro Figueiredo; TURCHI, Marília Dalva; SANTOS, Lyana Elias; GUIMARÃES, Eleuse Machado de Britto; GARCIA, Mônica Maria Danda; SEIXAS, Mirian Socorro Cardoso; VILLA, Luisa Lina; COSTA, Maria Cecília; MOREIRA, Marise Amaral Rebouças; ALVES, Maria de Fátima da Costa Alves. Prevalence, genotype profile and risk factors for multiple human papillomavirus cervical infection in unimmunized female adolescents in Goiânia, Brazil: a community-based study. BMC Public Health, New York, v. 13, n. 1041, 2013.