Calcium carbonate reduces iron absorption from iron sulfate, but not when iron is presented as an organic complex
Carregando...
Data
2005-03
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Experimental and epidemiological
evidences have demonstrated that calcium inhibits iron
absorption; calcium carbonate being one of the most
effective calcium sources to reduce iron absorption from
dietary origin or from iron sulfate. In the present work,
the short-term effect of calcium from calcium carbonate
on iron absorption was studied in rats, using different
iron compounds (monosodium ferric EDTA, iron-bysglicine,
iron peptide complex) with iron sulfate as a
control. Eighty (80) animals were divided into groups
of 10 animals each with homogeneous weight. After 18h
fast, the animals received by gavage 5 mL of a dispersion
containing one of the iron compounds (1mg Fe/kg body
weight), concomitantly or not with calcium carbonate
at a molar ratio of 150:1 (Ca/Fe). Two hours after the
administration, the animals were sacrificed and blood
was collected for serum iron determination (iron transfer
rate from intestinal lumen to blood compartment).
Additionally, the intestines were collected for soluble
iron determination (available iron). The results
demonstrated that calcium ion from calcium carbonate
inhibits the iron absorption from iron sulfate, but not
from organic iron (di- or trivalent) complexes.
Descrição
Palavras-chave
Iron absorption, Iron complexes, Calcium, Absorção de ferro, Ferro complexado, Cálcio
Citação
CONCEIÇÃO, Edemilson Cardoso da; MACHADO, Alexandre Alves; IZUMI, Clarice; FREITAS, Osvaldo de. Calcium carbonate reduces iron absorption from iron sulfate, but not when iron is presented as an organic complex. Alimentos e Nutrição, Araraquara, v. 16, p. 1-4, Jan./Mar. 2005.