Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18622
Tipo do documento: Artigo
Título: Diversification in the genetic architecture of gene expression and transcriptional networks in organ differentiation of Populus
Autor: Drosta, Derek R.
Benedicta, Catherine I.
Berg, Arthur
Novaes, Evandro
Novaes, Carolina Ribeiro Diniz Boaventura
Qibin, Yua
Dervinis, Christopher
Maia, Jessica
Yapc, John
Milesa, Brianna
Kirsta, Matias
Abstract: fundamental goal of systems biology is to identify genetic elements that contribute to complex phenotypes and to understand how they interact in networks predictive of system response to genetic variation. Few studies in plants have developed such networks, and none have examined their conservation among functionally specialized organs. Here we used genetical genomics in an interspecific hybrid population of the model hardwood plant Populus to uncover transcriptional networks in xylem, leaves, and roots. Pleiotropic eQTL hotspots were detected and used to construct coexpression networks a posteriori, for which regulators were predicted based on cis-acting expression regulation. Networks were shown to be enriched for groups of genes that function in biologically coherent processes and for cis-acting promoter motifs with known roles in regulating common groups of genes. When contrasted among xylem, leaves, and roots, transcriptional networks were frequently conserved in composition, but almost invariably regulated by different loci. Similarly, the genetic architecture of gene expression regulation is highly diversified among plant organs, with less than one-third of genes with eQTL detected in two organs being regulated by the same locus. However, colocalization in eQTL position increases to 50% when they are detected in all three organs, suggesting conservation in the genetic regulation is a function of ubiquitous expression. Genes conserved in their genetic regulation among all organs are primarily cis regulated (∼92%), whereas genes with eQTL in only one organ are largely trans regulated. Trans-acting regulation may therefore be the primary driver of differentiation in function between plant organs.
Palavras-chave: eQTL
Populus
Gene network
Gene regulation
Systems biology
País: Estados unidos
Unidade acadêmica: Escola de Agronomia e de Engenharia de Alimentos - EAEA (RG)
Citação: DROST, Derek R. et al. Diversification in the genetic architecture of gene expression and transcriptional networks in organ differentiation of ppulus. Proceedings of the National Academy of Sciences of the United States of America, Washington, v. 107, n. 18, p. 8492-8497, 2010.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1073/pnas.0914709107
Identificador do documento: 10.1073/pnas.0914709107
URI: http://repositorio.bc.ufg.br/handle/ri/18622
Data de publicação: 2010
Aparece nas coleções:ICB - Artigos publicados em periódicos

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