Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18629
Tipo do documento: Artigo
Título: Redundancy of proteins in the salivary glands of Panstrongylus megistus secures prolonged procurement for blood meals
Autor: Maranhão, Ana Carolina Bussacos
Nakayasub, Ernesto S.
Hechta, Mariana M.
Assumpção, Teresa Cristina França de
Rocha, Juliana Alves Parente
Soares, Célia Maria de Almeida
Santana, Jaime Martins de
Almeida, Igor Correia de
Teixeira, Antônio R. L.
Abstract: Panstrongylus megistus, a vector for the Chagas disease parasite Trypanosoma cruzi, is a hematophagous bug widely distributed in South America. This ubiquitous triatomine is known to colonize different wild life habitats. Additionally, P. megistus synanthropy, preying upon mammals, birds, reptiles, and eventually being predators upon insect's hemolymph probably increases its ability to survive after prolonged fasting. It was suspected that the P. megistus mechanisms of adaptation to survival might include a salivary gland complex tool-box with a diversity of pharmacologically active proteins for obtaining blood meals. Herein we describe comprehensive proteome and transcriptome of the P. megistus salivary gland. The proteomic analysis led to the identification of 159 proteins, and the transcriptome revealed 47 complete cDNAs. A diversity of protein functions associated to blood feeding was identified. The most prevalent proteins were related to blood clotting, anti-platelet aggregation and anti-vasoconstriction activities, which correlate with the insect's ability to obtain meals from different sources. Moreover, a gene of resistance to insecticides was identified. These features augments the comprehension towards P. megistus enormous capacity to survive in adverse wild life-changing habitats.
Palavras-chave: Hematophagous insect
Hemostasis
Proteomics
Salivary glands
Transcriptomics
Lipocalin
País: Outros
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: Bussacos, Ana C. M. et al. Redundancy of proteins in the salivary glands of Panstrongylus megistus secures prolonged procurement for blood meals. Journal of Proteomics, Amsterdam, v. 74, p. 1-8, 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1016/j.jprot.2011.04.028
Identificador do documento: 10.1016/j.jprot.2011.04.028
URI: http://repositorio.bc.ufg.br/handle/ri/18629
Data de publicação: 2011
Aparece nas coleções:ICB - Artigos publicados em periódicos

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