Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18630
Tipo do documento: Artigo
Título: Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon
Autor: Maranhão, Ana Carolina Bussacos
Nakayasub, Ernesto S.
Hecht, Mariana Machado
Rocha, Juliana Alves Parente
Soares, Célia Maria de Almeida
Teixeira, Antônio R. L.
Almeida, Igor Correia de
Abstract: The triatomines in the tribe Rhodniini are the main vectors of the Trypanosoma cruzi to humans in recent outbreaks of acute Chagas disease in the Amazon. These insects dwelling in palm trees do not colonize the human domicile. Their success to transmit the infection relies partially on the efficacy of their salivary gland apparatuses. Here we show the transcriptome of the Rhodnius brethesi and Rhodnius robustus salivary glands, comprising 56 and 122 clusters, respectively. Approximately one third of these clusters are described for the first time. The LC–MS/MS analysis identified 123 and 111 proteins in R. brethesi and R. robustus sialome, respectively. Noteworthy, lipocalin platelet aggregation inhibitors, inositol polyphosphate 5-phosphatases, and Kazal domain proteins, which are essential for the insect's successful acquisition of blood meals, were found in our analysis. Moreover, glutathione S transferase and antigen-5, which play roles in the insect's defense and resistance against insecticide, were also observed.
Palavras-chave: Haematophagous insects
Proteomics
Salivary glands
Transcriptomics
Salivary glands
Transcriptomic
País: Outros
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: BUSSACOS, Ana C. M. et al. Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon. Journal of Proteomics, Amsterdam, v. 74, n. 9, p. 1664-1672, 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1016/j.jprot.2011.06.022
Identificador do documento: 10.1016/j.jprot.2011.06.022
URI: http://repositorio.bc.ufg.br/handle/ri/18630
Data de publicação: 2011
Aparece nas coleções:ICB - Artigos publicados em periódicos

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