Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18687
Tipo do documento: Artigo
Título: Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)
Autor: Spíndula Filho, José Vieira de
Cruz, Aparecido Divino da
Leite, Angélica Ferreira Oton
Leles, Cláudio Rodrigues
Alencar, Rita de Cássia Gonçalves de
Saddi, Vera Aparecida
Mendonça, Elismauro Francisco de
Abstract: Human papillomavirus (HPV) has been cited as a possible initiating agent in the pathogenesis of oral cancer. However, the literature tends to be both controversial and inconclusive about the prevalence of HPV and its potential for proliferation in oral squamous cell carcinoma (SCC). The aim of this study was to investigate the cellular proliferation and the presence of HPV in SCC and verrucous carcinoma (VC). Forty-seven samples of SCC were selected and divided into three groups: 39 SCC, 8 VC, and 9 of normal mucosa (control-CT). Quantitative analyses of all groups showed a greater expression of PCNA, followed by Ki-67 and cyclin B1. A significant difference was observed in cyclin B1 expression in the SCC group compared with VC. PCNA, Ki-67, and cyclin B1 were statistically significant when comparing the SCC and CT groups. However, when SCC and VC were compared, there was no difference in Ki-67 expression. Our results showed that only cyclin B1 had an association with histological grade, and that poorly differentiated tumors presented a higher expression of cyclin B1. Therefore, considerable differences in the cellular proliferation between SCC and VC were observed, and no correlation with HPV was established, since all samples were negative for HPV.
Palavras-chave: Oral squamous cell carcinoma
HPV
Oral verrucous carcinoma
Cyclin B1
PCNA
Ki-67
País: Estados unidos
Unidade acadêmica: Faculdade de Odontologia - FO (RG)
Citação: SPÍNDULA-FILHO, José Vieira et al. Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV). Tumor Biology, New York, v. 32, n. 2, p. 409-416, 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1007/s13277-010-0135-4
Identificador do documento: 10.1007/s13277-010-0135-4
URI: http://repositorio.bc.ufg.br/handle/ri/18687
Data de publicação: 2011
Aparece nas coleções:FO - Artigos publicados em periódicos

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