Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19019
Tipo do documento: Artigo
Título: Expression of VEGF-A in intraepithelial and invasive cervical neoplasia
Autor: Westin, Maria Cristina do Amaral
Santos, Silvia Helena Rabelo
Andrade, Liliana Aparecida Lucci De Angelo
Derchain, Sophie
Pinto, Glauce Aparecida
Morais, Sirlei
Latuf Filho, Paulo
Zeferino, Luis Carlos
Abstract: Angiogenesis seems to be an early event that is associated with disease progression in cervical intraepithelial neoplasia (CIN). The aim of this study was to describe and analyze VEGF-A expression in CIN 3 and invasive cervical carcinoma, in tumor cells and stromal cells. This study comprised three groups: Group 1: 53 cases with CIN 3; Group 2: 24 cases with both CIN 3 and invasive carcinoma components; Group 3: 36 cases with invasive carcinoma. Protein expression was investigated in tumor and stromal cells by immunohistochemistry. Statistical analysis was carried out, considering the mean percentage of immunopositive cells. VEGF-A expression was higher in stromal cells in cases of invasive carcinoma (Group 3) than in CIN 3 cases (Group 1) and this difference was statistically significant. VEGF-A expression showed a borderline association between stromal cells in invasive carcinoma (Group 3) and invasive carcinoma associated with CIN 3 (Group 2). The mean percentage of cells expressing VEGF-A was significantly higher in tumor cells in CIN 3 than in stromal cells in CIN 3 (Group 1). The progression of CIN 3 to invasive carcinoma seems be determined by complex interactions between tumor and stromal cells. These findings reinforce the evidence of the role of stromal cells in tumor invasiveness
Palavras-chave: Angiogenesis inducers
VEGF-A
Uterine cervical
País: Belgica
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: WESTIN, Maria Cristina do Amaral et al. Expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasia. Journal of Cytology and Histology, Brussels, v. 2, nesp, p. 2-5, Nov. 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4172/2157-7099.S3-022
Endereço da licença: An error occurred getting the license - uri.
Identificador do documento: 10.4172/2157-7099.S3-022
URI: http://repositorio.bc.ufg.br/handle/ri/19019
Data de publicação: 18-Nov-2015
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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