Prognostic value of DNA and mRNA E6/E7 of human papillomavirus in the evolution of cervical intraepithelial neoplasia grade 2
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2014-02-28
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Objective: This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic
of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL).
Methods: This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy
performed every three months.
Results: Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up
were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P , 0.05). For women with HPV 16, the CIN
2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P , 0.05). The CIN 2 regression
rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically
significant.
Conclusions: The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very
high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a
prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be
considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.
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Viral oncogene proteins, Papillomavirus E7 proteins, E6 protein, Human papillomavirus-16, Cervical intraepithelial neoplasia, Neoplasm, Spontaneous, Disease progression
Citação
DISCACCIATI, Michelle Garcia et al. Prognostic value of DNA and mRNA E6/E7 of human papillomavirus in the evolution of cervical intraepithelial neoplasia grade 2. Biomarker Insights, London, v. 9, p.15-22, Feb. 2014.