Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19036
Tipo do documento: Artigo
Título: Prognostic value of DNA and mRNA E6/E7 of human papillomavirus in the evolution of cervical intraepithelial neoplasia grade 2
Autor: Discacciati, Michelle Garcia
Silva, Ismael Dale Cotrim Guerreiro da
Villa, Luisa Lina
Reis, Leandro
Hayashi, Priscila
Costa, Maria C.
Santos, Silvia Helena Rabelo
Zeferino, Luiz Carlos
Abstract: Objective: This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). Methods: This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Results: Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P , 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P , 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant. Conclusions: The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.
Palavras-chave: Viral oncogene proteins
Papillomavirus E7 proteins
E6 protein
Human papillomavirus-16
Cervical intraepithelial neoplasia
Neoplasm
Spontaneous
Disease progression
País: Gra-bretanha
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: DISCACCIATI, Michelle Garcia et al. Prognostic value of DNA and mRNA E6/E7 of human papillomavirus in the evolution of cervical intraepithelial neoplasia grade 2. Biomarker Insights, London, v. 9, p.15-22, Feb. 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4137/BMI.S14296.
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Identificador do documento: 10.4137/BMI.S14296.
URI: http://repositorio.bc.ufg.br/handle/ri/19036
Data de publicação: 28-Fev-2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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