Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19284
Tipo do documento: Artigo
Título: Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats
Autor: Pansani, Aline Priscila
Colugnati, Diego Basile
Schoorlemmer, Guus H. M.
Sonoda, Eliza Yumi de Freitas
Cavalheiro, Ésper Abrão
Arida, Ricardo Mario
Scorza, Fulvio Alexandre
Cravo, Sergio Luiz Domingues
Abstract: It is thought that cardiovascular changes may contribute to sudden death in patients with epilepsy. To examine cardiovascular alterations that occur during epileptogenesis, we measured the heart rate of rats submitted to the electrical amygdala kindling model. Heart rate was recorded before, during, and after the induced seizures. Resting heart rate was increased in stages 1, 3, and 5 as compared with the unstimulated control condition. In the initial one third of the seizures, we observed bradycardia, which increased in intensity with increasing stage and was blocked by injecting methyl atropine. During stage 5 seizures, a rebound tachycardia was observed that also increased in intensity with increasing number of seizures. This study demonstrated the influence of seizure frequency on cardiac autonomic modulation, providing a basis for discussion of potential mechanisms that cause patients with epilepsy to die suddenly.
Palavras-chave: Sudden unexpected death in epilepsy
Heart rate
Kindling
Seizure frequency
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: PANSINI, Aline P. et al. Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats. Epilepsy & Behavior, Amsterdã , v. 22, p. 442-449, 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1016/j.yebeh.2011.07.034Get
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
Identificador do documento: 10.1016/j.yebeh.2011.07.034Get
URI: http://repositorio.bc.ufg.br/handle/ri/19284
Data de publicação: 2011
Aparece nas coleções:ICB - Artigos publicados em periódicos

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