Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19287
Tipo do documento: Artigo
Título: Vasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora</i> ) extract in rats
Autor: Bufáiçal, Daniela Medeiros Lobo de Andrade
Reis, Carolina de Fatima
Castro, Patrícia Ferreira da Silva
Borges, Leonardo Luiz
Amaral, Nathalia Oda
Torres, Ieda Maria Sapateiro
Rezende, Stefani Garcia
Gil, Eric de Souza
Conceição, Edemilson Cardoso da
Pedrino, Gustavo Rodrigues
Rocha, Matheus Lavorenti
Abstract: This study’s aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and 𝛽- adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness.
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: ANDRADE, Daniela Medeiros Lobo de et al. Vasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora</i> ) extract in rats. Evidence-Based Complementary and Alternative Medicine, London, v. 2015, p. 1-8, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2015/696135
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
Identificador do documento: 10.1155/2015/696135
URI: http://repositorio.bc.ufg.br/handle/ri/19287
Data de publicação: 2015
Aparece nas coleções:ICB - Artigos publicados em periódicos

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