Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19297
Tipo do documento: Artigo
Título: Cardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: involvement of carotid body chemoreceptors
Autor: Pedrino, Gustavo Rodrigues
Rossi, Marcio Vinícius
Schoorlemmer, Guus H. M.
Lopes, Oswaldo Ubriaco
Cravo, Sergio Luiz Domingues
Abstract: The peripheral hyperosmolarity elicited by intravenous infusion of hypertonic saline brings potential benefits to the treatment of hemorrhage. The neural mechanisms involved in these beneficial effects remain unknown. The present study examines the role of carotid chemoreceptors in cardiovascular responses induced by hypertonic saline after hypovolemic hemorrhage in rats. Male Wistar rats (300–400 g) were anesthetized with thiopental, and instrumented for recording of mean arterial pressure. Arterial pressure was reduced to 60 mmHg by withdrawal of arterial blood over 10 min, and maintained at this level for 60 min by withdrawal or infusion of blood. In control rats (n=8) with intact chemoreceptors, the subsequent intravenous infusion of hypertonic saline (3 M NaCl, 1.8 ml kg−1 body weight, in 2 min) restored blood pressure (pressure increased from 61±4 to 118±5 mm Hg). In experimental rats (n=8), the carotid body arteries were tied, 30 min after the beginning of the hypotensive phase, leaving the carotid chemoreceptors ischemic. In these rats, hypertonic saline failed to restore blood pressure (pressure increased from 55±1 to 70±6 mm Hg). These findings suggest that the restoration of blood pressure after hypovolemic hemorrhage induced by hypertonic saline depends on intact carotid chemoreceptors.
Palavras-chave: Hypovolemic hemorrhage
Arterial blood pressure and heart rate
Hypertonic saline
País: Holanda
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: PEDRINO, Gustavo R. et al. Cardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: involvement of carotid body chemoreceptors. Autonomic Neuroscience: basic & clinical, Amsterdam, v. 160, p. 37-41, 2011.
Tipo de acesso: Acesso Aberto
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
URI: http://repositorio.bc.ufg.br/handle/ri/19297
Data de publicação: 2011
Aparece nas coleções:ICB - Artigos publicados em periódicos

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