Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19299
Tipo do documento: Artigo
Título: Impact of sex on hyperalgesia induced by sleep loss
Autor: Araújo, Paula Cristina Alves
Mazaro, Renata
Tufik, Sergio
Andersen, Monica Levy
Abstract: This study evaluated the impact of sex on the short term consequences of different periods of sleep deprivation and the effect of the respective sleep recovery periods on nociceptive responses. Male and female C57BL/6J mice were assigned to the following groups: paradoxical sleep deprived (PSD) for 72 h, sleep restricted (SR) for 15 days, exposed to respective recovery periods for 24 h, or untreated home-cage controls (CTRL). Mice were submitted to a noxious thermal stimulus to evaluate their nociceptive response after PSD, SR, or recovery periods. Blood was collected for hormonal analysis. The nociceptive response was significantly lower in PSD and SR mice compared to CTRL animals, regardless of the sex. However, SR females had a lower paw withdrawal threshold than males. Sleep recovery was able to restore normal nociceptive sensitivity after PSD in both sexes. The hyperalgesia induced by SR was not reversed by sleep rebound. In females, low concentrations of estradiol were found after SR, and these concentrations continued to decrease after 24 hours of sleep recovery. The PSD male mice exhibited higher concentrations of corticosterone than the CTRL and SR male mice. Corticosterone levels were not affected by SR. Our study revealed that PSD and SR induce hyperalgesia in mice. The SR groups showed marked changes in the nociceptive response, and the females were more sensitive to these alterations. This finding indicates that, although different periods of sleep deprivation change the nociceptive sensitivity in male and female mice, sex could influence hyperalgesia induced by chronic sleep loss.
Palavras-chave: Sleep deprivation
Hormones
Mice
Hyperalgesia
Sex differences
Corticosterone
Estradiol
País: Estados unidos
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: ARAUJO, P. et al. Impact of sex on hyperalgesia induced by sleep loss. Hormones and Behavior, New York, v. 59, p. 174-179, 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1016/j.yhbeh.2010.11.003
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
Identificador do documento: 10.1016/j.yhbeh.2010.11.003
URI: http://repositorio.bc.ufg.br/handle/ri/19299
Data de publicação: 2011
Aparece nas coleções:ICB - Artigos publicados em periódicos

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