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Tipo do documento: Artigo
Título: NK cells respond to pulmonary infection with mycobacterium tuberculosis, but play a minimal role in protection
Autor: Junqueira-Kipnis, Ana Paula
Kipnis, Andre
Jamieson, Amanda
Gonzalez Juarrero, Mercedes
Diefenbach, Andreas
Raulet, David H.
Turner, Joanne
Orme, Ian M.
Abstract: Both innate and adaptive immune systems contribute to host defense against infection with Mycobacterium tuberculosis. NK cells have been associated with early resistance against intracellular pathogens and are known to be potent producers of the cytokine IFN- . In C57BL/6 mice infected by aerosol exposure with M. tuberculosis, NK cells increased in the lungs over the first 21 days of infection. Expansion of the NK cell subset was associated with increased expression of activation and maturation markers. In addition, NK cells isolated from the infected lungs were capable of producing IFN- and became positive for perforin. In vivo depletion of NK cells using a lytic Ab had no influence on bacterial load within the lungs. These findings indicate that NK cells can become activated during the early response to pulmonary tuberculosis in the mouse model and are a source of IFN- , but their removal does not substantially alter the expression of host resistance.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: JUNQUEIRA-KIPNIS, Ana Paula et al. NK cells respond to pulmonary infection with mycobacterium tuberculosis, but play a minimal role in protection. The Journal of Immunology, Rockville, v. 171, n.11, p. 6039-6045, 2003.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4049/jimmunol.171.11.6039
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Identificador do documento: 10.4049/jimmunol.171.11.6039
Data de publicação: 2003
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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