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Tipo do documento: Artigo
Título: Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule
Autor: Kipnis, Andre
Basaraba, Randall J.
Turner, Joanne
Orme, Ian M.
Abstract: Up-regulation of expression of the cellsurface marker CD44 is a major characteristic of T lymphocytes responding in the lungs of mice infected with Mycobacterium tuberculosis. These lymphocytes express an activated/memory phenotype as seen by their high expression of the CD44 molecule and low expression of CD62L and CD45RB cell-surface molecules. Based on increasing evidence that the CD44 molecule participates in several aspects of the inflammatory response, we evaluated its role in the response to infection with M. tuberculosis using gene-disrupted mice. In this report, we show that CD44 expression is not necessary for the proper trafficking of protective cells to the lungs of mice infected with M. tuberculosis or the direct expression of protective immunity leading to control and containment of the bacterial load in this organ. However, although there were no differences in the bacterial load or migration of activated T lymphocytes to the inflamed lung, the absence of the CD44 molecule resulted in a substantially increased accumulation of neutrophils in the lung. These data indicate that loss of CD44 expression does not alter expression of T helper cell type 1 immunity to tuberculosis in the lungs but has major effects on the overall cellular composition of the immunopathological response.
Palavras-chave: Mouse
Lung inflammation
Tuberculosis infection
Cell recruitment
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: KIPNIS, Andre et al. Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule. Journal of Leukocyte Biology, New York, v. 74, n.6, p. 992-997, Dec. 2003.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1189/jlb.0603301
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Identificador do documento: 10.1189/jlb.0603301
Data de publicação: 2003
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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