Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19596
Tipo do documento: Artigo
Título: Hypertensive nephrosclerosis as a relevant cause of chronic renal failure
Autor: Caetano, Edna Regina Silva Pereira
Zatz, Roberto
Saldanha, Luís Balthazar
Praxedes, José Nery
Abstract: It is currently unclear whether hypertensive nephrosclerosis (HN), usually diagnosed solely on clinical grounds, is a relevant cause of end-stage renal disease. We biopsied 81 hypertensive outpatients (blood pressure $160/ 95 mm Hg) with moderate renal insufficiency, who were referred to our service from 1988 to 1998. Patients with known causes of hypertension, systemic disorders, rheumatic disease, or nephrotic syndrome were excluded. In 65% of patients, HN was the sole histological abnormality associated with renal dysfunction. Benign nephrosclerosis (BN), defined as isolated arteriolar hyalinosis and/or intimal fibrosis, was found in 18 HN patients (22%), whereas malignant nephrosclerosis (MN), denoted mainly by myointimal cell proliferation, appeared in 35 HN patients (43%). Previously undiagnosed primary nephritis (PN) was found in 13 patients (16%), whereas focal and segmental glomerulosclerosis, which might be either primary or secondary to hypertension, appeared in 15 patients (19%). These findings suggest that HN, in both its BN and MN forms, can be a definite cause of chronic renal insufficiency and that a substantial fraction of patients with renal insufficiency and clinical diagnosis of HN may actually have PN.
Palavras-chave: Nephrosclerosis
Hypertension
Essential
Kidney
Renal disease
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: CAETANO, Edna Regina Silva Pereira; ZATZ, Roberto; SALDANHA, Luís Balthazar; PRAXEDES, José Nery. Hypertensive nephrosclerosis as a relevant cause of chronic renal failure. Hypertension, Dallas, v. 38, n. 2, p. 171-176, Aug. 2001.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1161/01.HYP.38.2.171
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
Identificador do documento: 10.1161/01.HYP.38.2.171
URI: http://repositorio.bc.ufg.br/handle/ri/19596
Data de publicação: Ago-2001
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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