Efeito renoprotetor das drogas anti-hipertensivas

Abstract

It is well known the impact of systemic hypertension in the rate of loss of renal function in different clinical situations and experimental models. In kidney diseases hypertension entrances the renal injury and accelerates the outcome of chronic renal failure. Reduced renal man causes hemodynamic and functional adaptation in the remnant renal units that causes progressive glomerular sclerosis and interstitial fibrosis. Some anti-hypertensive drugs such as angiotensin connecting enzyme inhibitors cause efferent arteriolar vasodilation, reducing the glomerular hypertension and hyperfiltration, and by this effect can additionally protect the kidney, besides reducing the systemic arterial pressure. This renoprotective action well demonstrated in diabetic nephropathy is also evident in non-diabetic nephropathy. Besides the converting enzyme inhibitor, some nondihydropiridinic calcium channel blockers have similar effect. Therefore, anti-hypertensive treatment in patients with kidney disease must be choosing regarding renal function preservation.