Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/20807
Tipo do documento: Artigo
Título: Microemulsion based on Pterodon emarginatus oil and its anti‑inflammatory potential
Autor: Pascoa, Henrique
Diniz, Danielle Guimarães Almeida
Florentino, Iziara Ferreira
Costa, Elson Alves
Bara, Maria Teresa Freitas
Abstract: a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus (“sucupira”) oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1st, 7th, 15th, and 30th days after preparation and stored at different temperatures (5 ± 2 °C, 25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30- day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be more effective (p < 0.05) than the oil when applied directly to the ear.
Palavras-chave: Pterodon emarginatus/pharmacognosy
Pterodon emarginatus/óleo/atividade anti inflamatória
Tecnologia farmacêutica
Microemulsão
Fitoterápico
Plantas medicinais
País: Brasil
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: PASCOA, Henrique; DINIZ, Danielle Guimarães Almeida; FLORENTINO, Iziara Ferreira ; COSTA, Elson Alves; BARA, Maria Teresa Freitas. Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 51, n. 1, p. 117-125, Jan./Mar. 2015.
Tipo de acesso: Acesso Aberto
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
URI: http://repositorio.bc.ufg.br/handle/ri/20807
Data de publicação: Mar-2015
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