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Tipo do documento: Artigo
Título: Preparation and characterization of solid oral dosage forms containing soy isoflavones
Autor: Oliveira, Stela Ramirez de
Taveira, Stephânia Fleury
Marreto, Ricardo Neves
Valadares, Marize Campos
Diniz, Danielle Guimarães Almeida
Lima, Eliana Martins
Abstract: Soy isoflavones have been extensively used for menopausal symptoms and prevention of hormone-related cancer, osteoporosis and cardiovascular diseases. Commercially available forms of isoflavones include supplements, capsules and tablets. However, the non-standardization of soy isoflavones extracts and different dissolution profiles of these solid dosage forms highlight the need of additional studies on the development of well characterized pharmaceutical dosage forms of isoflavones. In this work, immediate release oral tablets of soy isoflavones were obtained and evaluated. Genistein and daidzein, were the main constituents of the dried soy extract. Preparation of the tables was accomplished in a rotary tableting machine following either a dry mixture for direct compression or wet granulation with different excipients. Powder, granules and tablets were evaluated for several parameters, including flow properties, Carr and Hausner indexes, hardness, friability, disintegration time and drug release profile. Also, a fast and validated HPLC analytical method for both genistein and daidzein was developed. Formulations containing sodium croscarmellose and sodium dodecyl sulfate resulted in better flowability as indicated by the flow rate and angle of repose, faster disintegration time and immediate release dissolution profile.
Palavras-chave: Daidzein
Isoflavone extract
País: Brasil
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: OLIVEIRA, Stela R. et al. Preparation and characterization of solid oral dosage forms containing soy isoflavones. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 1, p. 175-181, Jan./Feb. 2013.
Tipo de acesso: Acesso Aberto
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Data de publicação: Fev-2013
Aparece nas coleções:FF - Artigos publicados em periódicos

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