Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/20817
Tipo do documento: Artigo
Título: Dissolution test of herbal medicines containing Paullinia cupana: validation of methods for quantification and assessment of dissolution
Autor: Sousa, Sandra Alves de
Pascoa, Henrique
Conceição, Edemilson Cardoso da
Alves, Suzana Ferreira
Diniz, Danielle Guimarães Almeida
Paula, José Realino de
Bara, Maria Teresa Freitas
Abstract: “Guaraná” (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin), while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes, only capsule A showed at least 80% of the dissolved markers. In other capsules, marker dissolution did not exceed 60% whereas 60% of the samples had some characteristic pharmacotechnical problems. These results evidence the need for rigorous quality control to help ensure the therapeutic action of these drugs. To this end, dissolution studies are an essential tool for quality assurance of herbal medicines.
Palavras-chave: Herbal medicines/quality control
Paullinia cupana/pharmacognosy
Herbal medicines/dissolution behavior
Medicinal plants
Guaraná/pharmacognosy
País: Brasil
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: SOUSA, Sandra Alves de et al. Dissolution test of herbal medicines containing Paullinia cupana:validation of methods for quantification and assessment dissolution. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 47, n. 2, p. 269-277, June 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: https://doi.org/10.1590/S1984-82502011000200008
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
Identificador do documento: https://doi.org/10.1590/S1984-82502011000200008
URI: http://repositorio.bc.ufg.br/handle/ri/20817
Data de publicação: Jun-2011
Aparece nas coleções:FF - Artigos publicados em periódicos

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