Heparina: um estudo da literatura sobre características, propriedades físico-químicas e métodos aplicados à sua análise

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Data

2022-03-29

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Universidade Federal de Goiás

Resumo

Heparin belongs to the glycosaminoglycan family and is a natural polysaccharide derived from animal tissues, which has potent anticoagulant activity. It is a polymer, and is a molecule composed of repeating monomeric units and is mainly made up of 4 linked units of α-L-iaduronic acid 2-sulfate (α-IdA-2S) and α-D-glucosamine N,6-disulfated. The process of isolation of heparin is performed through the current legislation in Brazil, which aims to inspect its quality. Some techniques used for heparin quantification are: nuclear magnetic resonance, mass spectrometry and electrophoretic systems, turbidimetry and chromatographic methods. Thus, the study in question is a bibliographic, descriptive-exploratory and retrospective type analysis, with studies from 1991 to 2021, with integrative, systematized and qualitative analysis, having as general objective, to analyze the physical-chemical properties and the main analytical methods for quantification of heparin, raised from the technical-scientific literature. After defining the theme, a search was performed in virtual databases, the Virtual Library of the Scientific Electronic Library online (SciElo), Google Scholar and CAPES Periodicals. The terms "heparin", "heparin quantification" and "analytical methods" were used. The next step was an exploratory reading in the period from July 2021 to March 2022 of the publications from the years 1991 to 2021 were selected, thus characterizing the retrospective study. After the analysis of the selected articles, it was possible to conclude that heparin has several applications, and the forms of its investigation need to be expanded to better understand its mechanism of action in different systems.

Descrição

Palavras-chave

Heparina, Isolamento da heparina, Quantificação da heparina, Heparin, Heparin isolation, Heparin quantification

Citação

SOUSA, Thais Correia de. Heparina: um estudo da literatura sobre características, propriedades físico-químicas e métodos aplicados à sua análise. 2022. 29 f. Trabalho de Conclusão de Curso (Bacharelado em Farmácia) - Universidade Federal de Goiás, Goiânia, 2022.