Estudo clínico dos olhos de cães tratados com ciclosporina A (2%) que receberam implantes de córneas de suínos
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Data
1997
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Universidade Federal de Uberlândia
Resumo
Ten mixed breed dogs, with an average weight of 1 O kg, had swine corneas implanted in the left eye. During the post operative period each animal was treated with one drop of gentamicin and one drop of 2% cyclosporin per day until day 28, when they were sacrificed. Each cornea was examined every seven days using the direct ophthalmoscope to determine transparency, new vessel formation, episcleral and conjuntiva! vessel reaction, cornea thickiness, depth and presence or absence of deposits in the anterior chamber. Ali of the implanted corneas presented a slight opaqueness by day 7 postimplant, and a 90% opacity by day 28. New vessel formation, beginning with the limb as well as conjunctival vessel reactions, appeared between days 14 and 21, remaining in 90% of the grafted eyes. Just one eye (10%) had this condition atenuated. Ten eyes (100%) had the anterior chamber depth preserved and there weren't deposits. However, on day 7 PO three corneas (30%) presented edema, increasing to six corneas (60%) by day 14 PO and to ten corneas (100%) by day 21 PO. These alterations demonstrate macroscopically the impracticability of the homovital swine cornea penetrating xenotransplant in dogs for optical purposes, however, it may be useful for reconstrutive purposes.
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Canino, Suíno, Ciclosporina A, Xenotransplante, Córnea, Canine, Swine, Cyclosporin A, Xenotransplant
Citação
CHAVES, Nilo Sérgio Trancoso; BARROS, Paulo Sérgio de Moraes; MARTINS, Apóstolo Ferreira; ARAÚJO, Eugênio Gonçalves de; ARAÚJO, Larissa Franco de; EURIDES, Duvaldo; SILVA, Luiz Antônio Franco da. Estudo clínico dos olhos de cães tratados com ciclosporina A (2%) que receberam implantes de córneas de suínos. Veterinária Notícias, Uberlândia, v. 3, n. 1, p. 67-71, 1997.