Tenecteplase intracameral durante a facoemulsificação em coelhos: avaliação clínica do segmento anterior e análise bioquímica do humor aquoso
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Data
2020-07-16
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Editor
Universidade Federal de Goiás
Resumo
To evaluate the use of tenecteplase in transoperative
phacoemulsification in healthy rabbits, the study was carried
out with fifteen New Zealand rabbits, divided into three groups:
control group (CG), untreated group (UG) and treated group
(TG). UG and TG were operated by phacoemulsification and
TG received 50 μg / 0.3 mL of intracameral tenecteplase. The
postoperative evaluations were 24 h, 72 h, 7 days, 15 days and
21 days. In TP21 the animals were submitted to euthanasia
and aqueous humor samples were collected. No significantdifferences were observed in the clinical evaluations between CG and
TG in relation to incidence rates of intraocular pressure (IOP), corneal
edema, fibrin deposits, hyphema, aqueous flare and synechia. In the
physicochemical evaluation of the aqueous humor, there were no
significant differences between the three groups in relation to pH
values and concentrations of chloride ions. The aqueous humor density
values were statistically different between CG and the other groups.
In the histological evaluation, there were no significant differences
between the groups. The use of tenecteplase in transoperative
phacoemulsification in rabbits did not present significant differences
in terms of clinical, physicochemical and histological parameters.
Descrição
Palavras-chave
Catarata, Fibrina, Inflamação ocular, Oryctolagus cuniculus, Facoemulsificação, Tenecteplase, Cataract, Fibrin, Ocular inflammation, Phacoemulsication
Citação
PIVETA, Lidiane Cândida; OLIVEIRA, Helton Freires; REZENDE, Janayne Maria; MIGUEL, Marina Pacheco; LIMA, Aline Maria Vasconcelos; DAMASCENO, Adilson Donizeti. Tenecteplase intracameral durante a facoemulsificação em coelhos: avaliação clínica do segmento anterior e análise bioquímica do humor aquoso. Ciência Animal Brasileira, Goiânia, v. 21, n. 1, e-57717. 2020. Disponível em: https://revistas.ufg.br/vet/article/view/57717. Acesso em: 6 out. 2022.