Antiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) laves

Página do item simplificado
dc.creatorBannwart, Geanderson
dc.creatorOliveira, Cecilia Maria Alves de
dc.creatorKato, Lucilia
dc.creatorSilva, Cleuza Conceição da
dc.creatorRuiz, Ana Lúcia Tasca Gois
dc.creatorCarvalho, João Ernesto de
dc.creatorSantin, Silvana Maria de Oliveira
dc.date.accessioned2018-08-27T11:31:22Z
dc.date.available2018-08-27T11:31:22Z
dc.date.issued2013
dc.description.abstractAspidosperma macrocarpon belongs to the family Apocynaceae and is endemic to Americas and mainly found from Mexico to Argentina. It is known in Brazil as “guatambu” or “peroba”. Crude extracts and their fractions from leaves were assayed against human cancer cells lines: glioma (U251), melanoma (UACC- 62), mammary (MCF-7), ovarian expressing the multidrug resistance phenotype (NCI-ADR/RES), lung (NCIH460), prostate (PC-3), kidney (786-0), ovarian (OVCAR-3), colon (HT-29) and leukemia (K-562). The crude extract (EAM), hexane (HA) and chloroform (CA) fractions were the most active fractions against K-562 with GI50 values low than 1 μg/mL. Also, CA was moderate active against OVCAR-3 and NCI-ADR/RES cells lines. This phytochemical study allowed to identify the known kopsanone, kopsinine, ursolic acid, rutin, 5-Ocaffeoylquinic acid, and 3,5-O-dicaffeoylquinic acid. The kopsanone was also evaluated against human cancer cell lines and showed activity to the U251 and K-562 cell lines, with GI50 values of 20.6 μg/mL and 8.7 μg/mL, respectively.pt_BR
dc.identifier.citationBANNWART, Geanderson et al. Antiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) laves. Records of Natural Products, Gebze, v. 7, n. 2, p. 137-140, 2013.pt_BR
dc.identifier.issn1307-6167
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15745
dc.language.isoengpt_BR
dc.publisher.countryOutrospt_BR
dc.publisher.departmentInstituto de Química - IQ (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAspidosperma macrocarponpt_BR
dc.subjectAntiproliferative activitypt_BR
dc.subjectAlkaloidspt_BR
dc.titleAntiproliferative activity and constituents of aspidosperma macrocarpon (Apocynaceae) lavespt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - Geanderson Bannwart - 2013.pdf
Tamanho:
55.61 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IQ - Artigos publicados em periódicos