Chemical composition and antifungal activity of the essential Oil of hyptis ovalifolia benth
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Data
2004
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Resumo
The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the
resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the
essential oil was isolated by column chromatography and identified by spectroscopic methods as
(R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro
activity against four dermatophyte fungi Microsporum canis, Microsporum gypseum, Tricophyton
mentagrophytes, and Tricophyton rubrum (a total of 60 strains) with a minimal inhibitory concentration
observed in the range of 125-7.8 μg mL-1.
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Palavras-chave
Hyptis ovalifolia, Essential oil, Antifungal activity, Lamiaceae, (R)-6-[(Z)-1-heptenyl]- 5,6-dihydro-2H-pyran-2-one
Citação
OLIVEIRA, Cecília . M. A de et al. Chemical composition and antifungal activity of the essential oil of hyptis ovalifolia benth. (Lamiaceae). Journal of the Brazilian Chemical Society, Campinas, v. 15, n. 5, p. 756-759, 2004.