ESTUDO DO POTENCIAL MUTAGÊNICO E ANTIMUTAGÊNICO DA Solanum paniculatum L. PELO TESTE DO MICRONÚCLEO EM CAMUNDONGOS
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Data
2008-02-23
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Universidade Federal de Goiás
Resumo
Solanum paniculatum L., popularly known as jurubeba, is a widespread plant
species used in Brazilian folk medicine as a tonic, antifever agent, colagogue, bitter,
and eupeptic to treat liver and gastric dysfunctions. The chemical composition of
Solanum paniculatum has long been studied and many substances have been
isolated from the entire plant, including alkaloids, resins, glucids and saponins. The
aim of this study was to evaluate the mutagenic, antimutagenic and cytotoxic effects
of jurubeba s ethanolic leaf and fruits extracts using micronucleus test in mice bone
marrow. The experimental procedure was performed according Schimid (1975).
Swiss mice were orally treated with three different concentrations (100, 200 or 300
mg/kg) of leaf or fruit extracts of S. paniculatum. To evaluate the antimutagenic
activity were used the same doses of the extract simultaneously with a single dose of
Mitomicin C (4mg/kg) i.p. Cytotoxicity was evaluated by the polychromatic and normochromatic
erythrocytes ratio. Our results have indicated that the ethanolic leaf
extract of S. paniculatum did not exhibit mutagenic effect in mice, but it showed
antimutagenic effects in this extract towards MMC. The cytotoxicity was strongly
demonstrated specially for higher doses. Meanwhile, the ethanolic fruit extract of S.
paniculatum was mutagenic only in dose of 200 mg/Kg at time of 48 hours. It was
showed the cytotoxic activity for higher doses. However, no antimutagenic effect was
evidenced by fruit extract.
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Citação
VIEIRA, Pabline Marinho. STUDY OF POTENTIAL mutagenic and antimutagenic
THE Solanum paniculatum L. BY micronucleus test in
MICE. 2008. 69 f. Dissertação (Mestrado em Ciências Biolóicas) - Universidade Federal de Goiás, Goiânia, 2008.