Fatores de risco para o câncer do esôfago no Estado de Goiás
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Data
2012-05-10
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Universidade Federal de Goiás
Resumo
Context and Objectives: This thesis was divided into two parts. In the first one
risk factors for esophageal cancer were analyzed using data from a case and
control study. In the second part the survival of the esophageal cancer patients
from the first study was analyzed. The aim of this study was to evaluate the risk
factors for esophageal cancer in an area where the incidence is low and survival
of patients undergoing treatment in a low-volume hospital.
Methods: This is a case-control study hospital based. The analysed variables
were: sociodemographic data, habits, (tobacco and alcohol). The sample was
analyzed using the chi-square test, Mann-Whitney test and Mantel-Haenszel
approach for multivariate analysis. The strength of the risk was calculated using
odds ratios (OR) with significance defined at 5% and 95% confidence intervals.
Results: It was analysed 99 cases of esophageal cancer and 223 controls. The
risk of esophageal cancer was higher in patients ≥ 55 years (OR = 1.95; P=
0.01). Patients from rural areas had almost five times high risk in comparison
with urban. (OR 4.9; P < 0.001). Smoking was a risk factor among cases (OR =
3.8; P < 0.001), exposure to smoke from wood stoves (OR = 4.42; P < 0.001) as
well as frequent consumption of apples and pears OR 0,27 (CI95% 0,11 -0,70)
and fish OR 0,23 (CI 0,07 0,75), were found as protective factors. We
analysed the survival of 99 cases of the esophageal cancer. The average
survival was 32.7% for the first year, 25,2% for the second year and 11,0% for
the third year.
Conclusion: In a region in which the incidence of esophageal cancer is low, the
most significant risk factors were living rurally, smoking, exposure to a wood
stove and dary products consumption. Survival in patients with esophageal
cancer for the third year was 11%, the patients undergoing surgical treatment
survival in the third were 19,6%.
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MOTA, Orlando Milhomem da. Risk factors for esophageal cancer in the State of Goiás. 2012. 85 f. Tese (Doutorado em Ciencias da Saude) - Universidade Federal de Goiás, Goiânia, 2012.