Relação entre o perfil nutricional e parâmetros bioquímicos em crianças e adolescentes com diabetes mellitus tipo 1
Carregando...
Data
2010-05-18
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Introduction: Diabetes mellitus type 1 (DM1) is caused by partial or total destruction
of the beta cells of islets of Langerhans, with a resulting deficiency in insulin
production. Metabolic complications associated with type 1 diabetes results from
chronic hyperglycemia and are mainly cardiovascular diseases, which begin in the
first years after diagnosis, even in children and adolescents. Objective: To evaluate
the relationship between nutritional and biochemical profiles in children and
adolescents with DM1. Methods: Cross-sectional study with 54 patients treated at
the Clinic of Endocrinology, Hospital das Clinicas, Federal University of Goiás. Data
collected were: socioeconomic-demographic (age, sex, education, income), food
(dietetic habits, three 24-hour recalls); clinical (insulin), anthropometric (weight,
height, skinfolds, waist circumference-CC), biochemical (casual glucose GLC and
post-prandial GLPP, glycated hemoglobin HbA, lipid profile including triglycerides
TG, total seric cholesterol CTs, low density lipoprotein LDL, very low density
lipoprotein VLDL and high density lipoprotein HDL). Body fat was estimated using
the equation developed specifically for people aged eight to 18 years. HbA was
converted to an index (inHbA). Statistical analysis was performed using the statistical
package SPSS version 18.0. Were used descriptive statistics, Kolmogorov Smirnov
(p> 0.05), Student t test (p <0.05), qui square (p<0,05) and Pearson correlation (p
<0.05). Results: The average income per capita was R$ 263.8 ± 183.0 and insulin
therapy was mostly composed of three doses a day (72,2%). Most individuals
showed height (92.6%) and body mass index BMI (87%) appropriate for age. Those
with adequate glycemic control had lower GLC (p = 0.002) and GLPP (p <0.001).
Were identified correlations between inHbA and CC (p = 0.013), GLC (p = 0.014),
GLPP (p <0.001), TG (p <0.001) and VLDL (p <0.001). The consumption of sugary
products was mentioned by six per cent of the individuals. There was a higher
adequacy of parameters wich measure lipid profile compared to those which evaluate
glucose control: inHbA (64%); GLPP (18%), CTs (88%), LDL (92%), TG (76%) and
HDL (84%). There was negative correlation between CTs and carbohydrate intake
(r=- 0.324, p= 0.022) and positively with lipid (r= 0.315, p= 0.026), both after
adjustment for total calories, indicating that individuals who consumed a diet with
higher proportion of lipids and therefore with less carbohydrates, showed higher
concentrations of CTs. Conclusion: Glicemic control is associated with CC, GLC,
GLPP, TG and VLDL. The levels of CTs are directly associated with the consumption
of lipids.
Descrição
Palavras-chave
Citação
TELES, Sheylle Almeida da Silva. Relationship between nutritional profile and biochemical parameters in children and adolescents with type 1 diabetes mellitus. 2010. 119 f. Dissertação (Mestrado em Ciências da Saúde - Medicina) - Universidade Federal de Goiás, Goiânia, 2010.