Neurocisticercose Intraventricular experimental: Análise da resposta inflamatória
Carregando...
Data
2011-07-21
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Neurocysticercosis (NCC) is caused by Taenia solium cysticercus and is the main
cerebral infection caused by a parasite which can produce seizures and hydrocephaly. Besides
the considerable economic losses it is also responsible for over than 50 thousand annual
deaths. The use of experimental models has become a good method to the study of human
cysticercosis in several organs including the central nervous system. The most used parasite
is T. crassiceps cysticerci due to its rapid cycle of development and the antigenic similarity to
T. solium and its intraperitoneal model is the most diffused. The inoculation of Mesocestoides
corti cysticerci is the most common model of NCC used. Objectives: present a new
experimental model to NCC studies by using T. crassiceps cysticerci inoculated into four
different mice lineages (BALB/c, BALB/c KO-IL-4, C57BL/6 e C57BL/6 KO-IFNγ) and
evaluate the inflammatory response of these animals to the infection during 7, 30, 60 and 90
days after the infection (DAI). This new model showed itself useful into reproducing the
disease in animals resulting into lesions and alterations similar to the ones found in humans
and without significant damages in the control groups, which enables the study. We observed
that BALB/c mice are the less resistant to the infection, presenting greater ventriculomegaly,
inflammatory response with the prevalence of acute phase cells and late destruction of the
cysticerci when compared to C57BL/6 mice. The latter showed inflammation with prevalence
of mononuclear cells and greater efficiency in the destruction of the parasites. When
comparing the inflammatory response of conventional BALB/c mice to KO-IL-4 ones it was
possible to observe that the absence of IL-4 induces greater parasitism which favors the
cysticerci survival, less intensity of the inflammatory response, ventriculomegaly and
perivasculitis. Both lineages destroyed the cysticerci at the end of the late phase of the
inflammation process. When comparing the inflammatory response of conventional C57BL/6
mice to KO-IFNγ ones, the presence of IFNγ induced greater ventriculomegaly,
chronification of the inflammation, microgliosis and precocious destruction of the cysticerci.
In the absence of IFNγ the inflammatory response showed less intensity and late destruction
of the cysticerci.
Descrição
Palavras-chave
Citação
SILVA, Hidelberto Matos. Experimental Intraventricular neurocysticercosis:Analysis of the inflammatory response. 2011. 114 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Goiás, Goiânia, 2011.